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Scientists Study Barn Owls To Understand Why People With ADHD Struggle To Focus

Sep 11, 2018
Originally published on September 12, 2018 8:22 am

Kids with ADHD are easily distracted. Barn owls are not.

So a team at Johns Hopkins University in Baltimore is studying these highly focused predatory birds in an effort to understand the brain circuits that control attention.

The team's long-term goal is to figure out what goes wrong in the brains of people with attention problems, including attention deficit hyperactivity disorder.

"We think we have the beginnings of an answer," says Shreesh Mysore, an assistant professor who oversees the owl lab at Hopkins. The answer, he says, appears to involve an ancient brain area with special cells that tell us what to ignore.

Mysore explains his hypothesis from one of the owl rooms in his basement lab. He has a distraught bird perched on his forearm. And as he talks, he tries to soothe the animal.

The owl screeches, flaps and digs its talons into the elbow-length leather glove that Mysore wears for protection. He covers the bird's eyes with his free hand and hugs the animal to his chest.

The owl, no longer able to focus on the movements of his human visitors, goes quiet.

When it comes to paying attention, barn owls have a lot in common with people, Mysore says.

"Essentially, a brain decides at any instant: What is the most important piece of information for behavior or survival?" he says. "And that is the piece of information that gets attended to, that drives behavior."

For a hungry owl, important information might be the sound of a wood mouse scampering through the grass. For a human parent, it might be the cry of a baby in the next room.

In either case, hearing the sound causes a distinct response in the brain.

"When we pay attention to something, we're not just focusing on the thing that we want to pay attention to," Mysore says. "We're also ignoring all the other information in the world."

"The question is, how," he says. "How does the brain actually help you ignore stuff that's not important for you?"

Mysore believes answering that question could help people whose brains are vulnerable to distractions. That includes not only people with ADHD, he says, but also many with autism, schizophrenia and even Parkinson's disease.

"Pretty much name a psychiatric disorder, and there is some kind of attentional deficit associated with it," Mysore says.

The problem is that scientists still don't know much about the brain's system for suppressing distractions.

There's no simple way to study it in a human brain, Mysore says, but owl brains offer a good substitute. The birds have a predator's ability to focus, as well as keen eyesight and hearing. They also have a brain organized in a way that's easy to study.

Because owls have eyes that are fixed in their sockets, the birds must swivel their head to look around. That makes it straightforward for the researchers to tell what they're paying attention to.

So Mysore's lab is doing experiments in which an owl must decide whether to focus on something it hears or something it sees. For example, an owl might be listening to bursts of noise coming through special earphones while a computer monitor shows an object approaching quickly.

That sets up a competition between these stimuli in the midbrain, an ancient part of the brainstem that can be found in animals ranging from reptiles to people.

"And when we're presenting these stimuli, we're measuring activity in key areas in the midbrain to try and figure out how that stimulus competition is actually being implemented or carried out by neurons in the brain," he says.

Several years ago, Mysore and Eric Knudsen, a professor at Stanford, identified a system in the owl midbrain that appears to control which stimulus to ignore. Now, Mysore's lab is trying to understand exactly how that system works.

"One of the coolest things has been the identification of a particular group of neurons in the midbrain that we think are the ones controlling distractor suppression," he says.

In other words, these seem to be the precise neurons that tell a brain when to start ignoring sights and sounds that aren't important at that moment.

That could be critical to understanding why people with attention disorders have so much trouble ignoring distractions, Mysore says.

The lab's next challenge is to show that mice, and people, also have these special neurons. If they do, Mysore says, it could provide a new target for treatments aimed at a wide range of disorders that affect attention.

Copyright 2018 NPR. To see more, visit http://www.npr.org/.

AUDIE CORNISH, HOST:

Children with ADHD have trouble staying focused, but it's not clear why they're so vulnerable to distractions. That's why scientists are studying the brain of a predator bird that relies on intense focus to survive. NPR's Jon Hamilton reports on a lab at Johns Hopkins University that specializes in barn owls.

JON HAMILTON, BYLINE: The barn owls live in a basement, and they make their nests in wooden boxes.

NAGARAJ MAHAJAN: So I'm just going to go tap the box, and hopefully one of them will fly out.

(SOUNDBITE OF POUNDING)

HAMILTON: Nagaraj Mahajan is a researcher here who works with the owls a lot, but today, they're ignoring him.

MAHAJAN: There are three birds in here, so I'm just going to grab one of them.

HAMILTON: The barn owl he grabs has other plans.

(SOUNDBITE OF OWL SCREECHING)

HAMILTON: It also has sharp talons and a beak that can shred a small rodent, which is why Mahajan is wearing welding gloves and a face shield. Eventually, he gets his bird.

(SOUNDBITE OF OWL SCREECHING)

HAMILTON: Mahajan hands the owl to his boss, Shreesh Mysore, who covers the bird's eyes with one hand and hugs it to his chest with the other. Mysore says barn owls have a lot in common with people when it comes to paying attention.

SHREESH MYSORE: Essentially, a brain decides at any instant what is the most important piece of information for behavior or survival. And that is the piece of information that gets attended to or, in other words, that drives behavior.

HAMILTON: For a hungry owl, that might be the sound of a wood mouse scampering through the grass. And when the owl hears that sound, it doesn't just zero in on its prey. Mysore says it tunes out all the other sights and sounds around it.

MYSORE: When we pay attention to something, we're not just focusing on the thing that we want to pay attention to. We're also ignoring all the other information in the world, right? The question is how? How does the brain actually help you ignore stuff that's not important for you?

HAMILTON: That's what Mysore's lab has been studying in these barn owls. And he says someday what he's learning might help explain attention problems in people.

MYSORE: For instance, ADHD patients have trouble ignoring even light sounds, or, you know, dim flashes of light tend to distract them from their task. Well, why? One hypothesis is that maybe the system in the brain that is supposed to be doing it, that's in charge of suppressing the distractors isn't quite working well.

HAMILTON: But scientists don't know much about this system in people. They're not even certain where it exists in the human brain. Mysore says barn owls may provide some clues. They have a predator's ability to focus, keen eyesight and hearing and brains that are organized in a way that's easy to study. So his lab is doing experiments that have an owl choose whether to focus on something it hears or something it sees. For example, the owl might be presented with bursts of noise while a computer monitor shows an object that appears to be approaching quickly.

MYSORE: And when we are presenting these stimuli, we're measuring activity in key areas in the midbrain to try and figure out how that stimulus competition is actually being implemented or carried out by neurons in the brain.

HAMILTON: Earlier experiments with birds had suggested that decisions about attention involve the midbrain, an ancient part of the brain stem. Mysore says now his team is figuring out exactly which brain cells are doing the deciding.

MYSORE: One of the coolest things has been the identification of a particular group of neurons in the midbrain that we think - we have a strong hypothesis that they are the ones that are controlling distractor suppression.

HAMILTON: In other words, the neurons that tell a brain when to ignore stuff that isn't important at that moment. Mysore says the next step is to demonstrate that mice and people also have these special neurons. And if they do, he says, it could help scientists understand how a wide range of disorders are affecting a critical system in the brain.

MYSORE: We know that deficits of attention are found in numerous psychiatric disorders, so not just ADHD or autism but schizophrenia, Parkinson's. And pretty much name a psychiatric disorder, there is some kind of attentional deficit associated with it.

HAMILTON: A deficit that just might be explained by a barn owl.

(SOUNDBITE OF OWL SCREECHING)

HAMILTON: Jon Hamilton, NPR News. Transcript provided by NPR, Copyright NPR.